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June 20, 2007 22:23:13 WIB
Regional Chemotherapy

Informasi dikumpulakan oleh Grace-Melbourne

Dear All
Ini just for your information saja
siapa tau bisa berguna bagi penderita , atau informasi bagi para ahli kedokteran, Bukan jualan dan mengiklankan hal ini, just informasi, siapa tau ada yang cocok dan ada yang selamat/sembuh, kan menyenangkan banyak orang.

Regional Chemotherapy

A Pioneer of Regional Chemotherapy

Prof Aigner born in Burgause /Bavaria, studied medicine at Erlangen University ,where also began his training as cardiovascular surgeon At the university of Giessen Centre for General and Thoracic surgery , he devoted his prof.ial thesis to " Techniques in Regional Chemotherapy" as part of his academic focus on surgical oncology

in 1981, Prof Aigner developed a technique to perform the first ever isolated perfusion of human liver, using a heart-lung machine. in the following years, he developed a wide range of surgical techniques , and devised special catheters for the isolated treatment of organs and body parts, amongst them for pancreatic cancer

in 1982, Prof Aigner initiated a series of international congresses on Regional Chemotherapy ( ICRCT) and from 1985 events by the international Society Regional Cancer Treatment ( ISRCT)

He gave lectures and performed operations as a visiting surgeon in The US, in JApan, China, Israel, Egypt, Australia, and within many European contries

since 2002, Prof Aigner is in charge of the department for oncological Surgery at the Medias Klinik in Ransbach- Baumbach

Prof Aigner is one of the worlds pioneers in Regional Chemotherapy. For more than 25 years, he has been involved with Regional Chemotherapy ( RCT) and is now worldwide one of the most experienced practitioners of this treatment method

Regional Chemotherapy ( RCT) a different kind of chemotherapy

For Cancer patients whose tumours have already metastasized, conventional intravenous chemotherapy is often the final option to reduce their suffering.For decades now, this method has been used to introduce cytotoxins (cytostatic agents) into the body's entire circulatory system

The disadvantages of this treatment option are only too familiar to most patients who have received it and also to their families : The cytotoxins not only damage the tumour cells, but also other, healty cells. for example they distroy the hair follicles, bone marrow, the muccous membranes of the digestive tract, and they lower the white blood cell count. in consequence, patient lose their hair and complain about severe nousea and physical exhaustion

In contrast with intravenous Chemotherapy, Regional Chemotherapy is a local treatment option, restricted to the region of the body actually affected by the tumour

the result in a number of advantages

In RCT the anticancer agent is always administered via the artery supplying the tumour or the tumour region. In that way, the tumour toxic subtances can be infused through the affected region in very high effect concentrations. This in turn results in a higher transfer of these cytotoxins into the tumour cells and thus in a better drug effect in the target area.

RCT a highly concentrated chemotherapy to inflict lasting damage on solid tumours

some tumours require treatment with an extremely high concentration of the antitumours drug, others shrin'x even at lower concentrations. As a rule of thumb, six times the concentration used in conventional chemotherapy is necessary to cause lasting damage to a solid tumours

Using a range of techniques, Regional Chemotherapy can achieve a cytostatic concentration at the tumour that is three to ten times , and in extreme cases up to seventy times higher, and thus also a different effectiveness than in conventional chemotherapy

another decisive factor in the therapeutic success, though, is the blood supply ( vascularization) of the tumour through blood vessels. If the blood supply to the tumours is poor, then even the direct arterial route will only be able to delivery a small amount of the cystostatic drug to it

Using RCT as a pretreatment

make the surgical removal of the shrunken tumours much easier for Prof Aigner and his team at a much reduced risk to the patient,shortens any stay in hospital,largely reduces the ability of the tumours to metastasize as a result of manipulation during its surgical removal.

In the best -case schenario, the tumour will completely disappear prior to any operation.

More quality of life as a result of detoxification

Because Regional chemotherapy is only ever limited to one region of the body or one organ, patients experience few whole body side effects despite its high degree of effectiveness at the tumour.

This is not least due to the chemofiltration, which follow each therapeutic intervention in order to ensure the sytemic detoxification of the body

This method of treatment is highly beneficial to our parents

Most patient tolerate this treatment particulary well, The quality of life is rarely negatively affected,and sometimes even improved. Under normal circumstances, our patients do not suffer from nausea at any stage of their treatment.

Techniques of RCT

all the techniques that Prof Aigner and his team have developed for the regional chemostherapeutical treatment are disigned to keep any surgical intervention as small as possible.
Arterial infusion

for an arterial Infusion, a catheter is inserted under local anaesthesia into the artery in groin and then under x-ray control advanced to the tumour region
advantage : small surgical intervention
disadvantage : the patient has to observe 3 or 4 days of strict bed rest

Surgical application

In this method, an arterial port catheter is surgically implanted into the artery supplying the tumour. In that way the tumour can be treated right at the tumour focus, as often as required, without the need for a repeated surgical intervention.

Advantage: the patient is postoperatively mobile,as the arterial infusion is administered via the punctured port. the operation provides better insight into the spread of the tumour ( stafing ) disadvantages: requires surgery

Isolated perfusion

Isolated perfusion is also performed surgically, by isolating and organ or a body region using a catheter system and by perfusing this region with a high concentration of cystostatic the same time ,heat is applied to the tumour (hyperthermia) and /or the oxygen content of the blood reduced (hypoxia), resulting for some cystostatic agents in an up to tenfold increase in tumour toxicity. Advantage: the tumour dissapears more quickly.

RCT - but for whom ?

RCT is suitable for patients with solid tumours, however, not all types of tumours respond in the same way to highly concentrated chemotherapy. Prof Aigner : " Our method either works immediately or not at all "

Whether are not the treatment with RCT will be successful depends on a range of factors, such as : the sensitivity and blood supply of the primary or secondary tumours and also whether the tumour localized, confined to one organ, or spread over several regions of the body basically the same principle applies as in conventional cancer therapy. the larger the body volume affected by the tumour, the lower the changes of success.

Why ?

Even in RCT, it is not possible to increase the total administered dose at will. if this comparatively constant quantity of cystotoxins has to be spread across larger tumours or tumours regions, the effective concentration is correspondingly lower, and the effect of the cystostatic agents thus reduced. In the early stages of the disease, RCT works particulary well in the treatment of tumours. However Prof Aigner and his team have also achieved great successes in the later, more advanced stages

What kind of tumours can be terated with RCT ?
tumours with good response rate : Breast Cancer ( primary and metastazed) Head - neck tumours Stomach cancer Bladder Cancer Prostate cancer Ovarian cancer Cholangiocarcinoma Anal Cancer Hypernephroma Thyroid cancer Oesophageal cancer Carcinoids

Tumours with a moderate to good response rate : Bronchial carcinoma Pancreatic carcinoma Hepatocellular carcinoma Soft tissue sarcomas Malignant melanoma cervical cancer

tumours with a poor to moderate response rate : Colon and rectal cancer

wah capai juga ngetik nya,
setahu saya yang sudah menerapkan teknik ini, di Japan banyak kayaknya ( sudah familiar di sana), di RS Fuda Guangzhou, di RSPAD jakarta ( dr Terawan) sptnya segera menyusul di rs2 lain, soalnya udah beberapa dokter lain belajar teknik ini, di singapore kalau tidak salah dr Ang ( kepanjangannya lupa)

kalau yang di tempat Prof Aigner ini :
tel : + 49 2623 890 554 fax + 49 2623 890 486

The medias Klinik in Ransbach-Baumbach is easily accessible in the triangle between motorways A3 and A 48 , almost exactly half way between Franfurt and Cologne

address : Medias
Surgical Oncology GmbH
Erlenhofstrabe 3 D56235 Ransbach - Baumabch

semoga berguna , ya setidaknya menambah informasi

salam, Grace-Melbourne

Komentar Saputra:

tambahan info: klikRegional Chemotherapy gives hope

dan klik medizinisches Dienstleistungszentrum an der Salzach(medias)

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